Cyclobenzaprine Flexeril Side Effects, Interactions, Uses, Dosage, Warnings
Drug interactions can occur when one medication interferes with the removal of another medication. Ciprofloxacin can inhibit (prevent the activity) one of the pathways that is used to eliminate medications from the body. This pathway works through an enzyme in the liver known as cytochrome P450 1A2.
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Drug interactions are often responsible for the causation of this syndrome. In both cases, symptoms of autonomic instability and severe agitation started within hours of initiation of cyclobenzaprine and fully resolved within 3 days after discontinuing the proserotoninergic drugs. We conclude that cyclobenzaprine should be used with extreme caution in patients receiving other serotonin-enhancing drugs; these patients should be closely monitored for manifestations of serotonin syndrome.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Before taking cyclobenzaprine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
- Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
- Cyclobenzaprine can increase the effects of CNS depressants, such as alcohol, opioids, allergy medications, and sleeping pills.
- Patients with low back pain or fibromyalgia may benefit from treatment with cyclobenzaprine.
- Only trained and licensed medical professionals can provide such services.
For non-prescription products, read the label or package ingredients carefully. To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk with your doctor or pharmacist. Cyclobenzaprine usually begins working about one hourafter it is ingested, relaxing muscles and relieving muscle spasms.
Higher doses of cyclobenzaprine or tizanidine would be appropriate to promote sedation in cases of more severe discomfort or perceived muscular spasm. Although there appears to be insufficient data on metaxalone and methocarbamol, these may be useful in patients who cannot tolerate the sedative properties of cyclobenzaprine or tizanidine. Of note, methocarbamol costs substantially less than metaxalone.
This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription. If you have liver problems, your doctor may do a blood test to monitor how well your liver is working while you take this drug. You should not need a new prescription for this medication to be refilled.
Because of limited comparable effectiveness data, choice of agent should be based on side-effect profile, patient preference, abuse potential, and possible drug interactions. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.
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Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. This medication has been prescribed for your current condition only.
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Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.